Title : Cell division patterns in acute myeloid leukemia stem - like 1 cells determine clinical course : a model to predict patient survival
نویسندگان
چکیده
3 Authors: Thomas Stiehl, Natalia Baran, Anthony D Ho, Anna Marciniak4 Czochra 5 6 7 Institute of Applied Mathematics, University of Heidelberg, Im Neuenheimer Feld 8 294, 69120 Heidelberg, Germany 9 10 Bioquant Center, University of Heidelberg, Im Neuenheimer Feld 267, 69120 11 Heidelberg, Germany 12 13 Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Im 14 Neuenheimer Feld 368, 69120 Heidelberg, Germany 15 16 Department of Medicine V, Medical Center, University of Heidelberg, Im 17 Neuenheimer Feld 410, 69120 Heidelberg, Germany. 18 19 20 Running title: Estimation of leukemic stem cell properties 21 22
منابع مشابه
Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course: a model to predict patient survival.
Acute myeloid leukemia (AML) is a heterogeneous disease in which a variety of distinct genetic alterations might occur. Recent attempts to identify the leukemia stem-like cells (LSC) have also indicated heterogeneity of these cells. On the basis of mathematical modeling and computer simulations, we have provided evidence that proliferation and self-renewal rates of the LSC population have great...
متن کاملIntegrated Systems and Technologies: Mathematical Oncology Cell Division Patterns in Acute Myeloid Leukemia Stem-likeCellsDetermineClinicalCourse:AModel to Predict Patient Survival
Acute myeloid leukemia (AML) is a heterogeneous disease in which a variety of distinct genetic alterations might occur. Recent attempts to identify the leukemia stem-like cells (LSC) have also indicated heterogeneity of these cells. On the basis of mathematical modeling and computer simulations, we have provided evidence that proliferation and self-renewal rates of the LSC population have great...
متن کاملKIR2DS3 is Associated with Protection against Acute Myeloid Leukemia
Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML;...
متن کاملCDKN2B methylation correlates with survival in AML patients
Aberrant DNA methylation has been reported as an important phenotype in acute myeloid leukemia. However the clinical significance of methylation changes has not been clear yet. In this study methylation Specific Melting Curve Analysis (MS-MCA) and real time PCR was used to assess the CDKN2B promoter hyper-methylation and gene expression in 59 Iranian acute myeloid leukemia (AML) patients. The i...
متن کاملCDKN2B methylation correlates with survival in AML patients
Aberrant DNA methylation has been reported as an important phenotype in acute myeloid leukemia. However the clinical significance of methylation changes has not been clear yet. In this study methylation Specific Melting Curve Analysis (MS-MCA) and real time PCR was used to assess the CDKN2B promoter hyper-methylation and gene expression in 59 Iranian acute myeloid leukemia (AML) patients. The i...
متن کامل